8 Perfect Weekend Getaways from St Louis, MO

If you live in or near St Louis, Missouri, you're ideally positioned for a variety of weekend escapes that blend scenic beauty, cultural richness, lively city energy, and serene nature. These destinations range from under two hours away, perfect for a quick and rejuvenating break - to those a bit further out, ideal for a long weekend adventure. Whether you crave intimate bed-and-breakfast charm, bustling urban scenes, family-friendly entertainment, or outdoor pursuits, there's a weekend getaway from St Louis MO to suit your style and timeframe.

Expect drive times from about 90 minutes to just under five hours, making it easy to leave Friday afternoon and come home refreshed Sunday evening. Most trips outlined here can be comfortably enjoyed over two days, with recommended lodging, dining, and activities that maximize your limited time.

Quick Overview: Best Weekend Getaways from St Louis

• Hermann, Missouri – 80 miles / 1.5 hours
• Shawnee National Forest, Illinois – 125 miles / 2 hours
• Lake of the Ozarks, Missouri – 170 miles / 2.75 hours
• Kansas City, Missouri – 250 miles / 3.75 hours
• Branson, Missouri – 255 miles / 4 hours
• Louisville, Kentucky – 260 miles / 4 hours
• Indianapolis, Indiana – 245 miles / 4 hours
• Nashville, Tennessee – 310 miles / 4.75 hours

Hermann, Missouri

Just 1.5 hours from St Louis, Hermann is Missouri's premier wine country, with a captivating German heritage that imbues its charming downtown and rolling vineyards. This intimate town is ideal for a romantic weekend or a relaxing getaway, offering historic bed and breakfasts, award-winning wineries, and picturesque views along the Missouri River. Its proximity makes it feasible to savor the pace and beauty without feeling rushed.

Best Hotels to Stay in Hermann

• Hermann Hill – A luxury inn and spa perched bluff-top with private jacuzzis and fireplaces. Perfect for a romantic splurge, with thoughtful hospitality touches like gourmet breakfast in your suite.
• Inn at Hermannhof – Historic inns and cottages meticulously restored from the 19th century. Ideal for history buffs and lovers of cozy, romantic atmospheres, with wine cellars beneath your feet.
• Hermann Crown Suites – Midrange, family-friendly all-suite hotel featuring multi-room suites and a unique underground bar in a historic firehouse. Great for groups needing space and a lively setting.

Best Restaurants to Try in Hermann

• Tin Mill Restaurant – Authentic German-American dishes in a 19th-century grain mill setting. Don't miss the Jägerschnitzel for a rustic, traditional experience.
• Hermann Wurst Haus – A casual, budget-friendly working butcher shop famous for award-winning sausages. Their Best-of-Show Bratwurst Platter is a must-try, and you can even take sausage-making classes.
• Fernweh Distilling Co. – Modern craft distillery and kitchen with inventive cocktails like the Smoked Old Fashioned, paired brilliantly with comfort food such as Brisket Mac & Cheese.

Best Things to Do in Hermann

• Hermann Wine Trail: Explore seven family-owned wineries along a scenic 20-mile stretch, easily hopping on and off the Hermann Trolley for a romantic, leisurely day of tastings.
• Deutschheim State Historic Site: Gain insight into Hermann's German immigrant roots by touring preserved 1840s homes—educational and budget-friendly.
• Katy Trail State Park: Rent a bike and cruise a flat, scenic portion of America's longest rail-to-trail conversion, with views of the Missouri River and access to wineries.

2-day Itinerary in Hermann

Day 1: Arrive and settle into your bed and breakfast, then stroll downtown browsing antique shops. Dinner at Tin Mill Restaurant serves up authentic local flavors. Cap the night with a cocktail at Fernweh Distilling Co.

Day 2: Start with a leisurely breakfast, then take the Hermann Trolley to visit several wineries like Stone Hill and Adam Puchta for tastings. Grab lunch at Hermann Wurst Haus before heading back to St Louis.

Insider Local Tips

• Visit on weekdays or non-festival weekends to enjoy quieter wineries and dining experiences; Sunday evenings through Thursday are especially tranquil.
• Don't try to cram all wineries into one day—pick a few favorites to savor. Rushing dilutes the experience.
• For popular festivals like Oktoberfest, book lodging 6–12 months in advance. For regular weekends, 1–2 months ahead usually suffices.
• Skip the busy main street crowd and check out Black Shire Distillery for a more intimate spirits tasting.

Best Time to Visit Hermann

Fall (September–October) is ideal for Oktoberfest celebrations and vivid foliage, while Spring (April–May) brings milder weather and fewer tourists, perfect for outdoor and winery visits.

Shawnee National Forest, Illinois

Just two hours from St Louis, Shawnee National Forest offers an affordable, nature-focused escape with stunning geological formations and top-tier hiking trails. If your weekend getaway from St Louis MO leans toward rugged outdoor adventure combined with serene quiet, Shawnee is a perfect choice, also featuring a growing wine trail for variety.

Best Hotels to Stay in Shawnee National Forest Area

• Giant City Lodge – Historic state park lodge built by the Civilian Conservation Corps, rustic and family-friendly with immediate trail access and a renowned family-style fried chicken dinner.
• Makanda Inn & Cottages – Secluded, romantic cottages nestled in the woods offering quiet and modern comforts, ideal for unwinding after a day exploring nature or the nearby wine trail.
• Havisham House – Charming, historic B&B in Alto Pass with personalized service, placing you right on the Shawnee Hills Wine Trail for relaxed touring.

Best Restaurants to Try in Shawnee National Forest

• 17th Street BBQ – Casual, award-winning barbecue destination famous for legendary baby back ribs; a must-try for barbecue lovers.
• Scratch Brewing Company – Unique farmhouse brewery and kitchen known for beers brewed with foraged ingredients; pair a seasonal draft with their sourdough pizza.
• Giant City Lodge Restaurant – Classic regional comfort food in a cozy setting; their all-you-can-eat family-style fried chicken is a beloved staple.

Best Things to Do in Shawnee National Forest

• Garden of the Gods Recreation Area: Short but spectacular hikes through towering sandstone formations with panoramic views—perfect for stunning photos and easy exploration.
• Shawnee Hills Wine Trail: Scenic drive connecting 11 local wineries offering tastings, live music, and food on weekends—romantic and leisurely.
• Giant City State Park: Explore massive bluffs and a short nature trail winding through striking rock walls. Family-friendly and accessible.

2-day Itinerary in Shawnee National Forest

Day 1: Arrive and hike Garden of the Gods in the afternoon. Check into your lodge or cabin. Dinner at Scratch Brewing Company combines great beer and creative meals.

Day 2: Morning visit to Giant City State Park followed by the classic fried chicken lunch at Giant City Lodge. Spend the afternoon winery hopping on the Shawnee Hills Wine Trail before returning to St Louis.

Insider Local Tips

• Garden of the Gods is popular on fall weekends; arrive before 10 AM for parking and a quieter experience.
• Cell service is very limited; bring offline maps or a paper map to avoid getting lost on remote trails.
• Reserve cabins and rooms early—especially for fall foliage season; popular accommodations book months ahead.
• Visit Makanda’s quirky 1890s boardwalk with artist studios for a fun detour between hiking and wineries.

Best Time to Visit Shawnee National Forest

Fall (October–November) is outstanding for vibrant colors and pleasant hiking weather. Spring (April–May) also offers mild temperatures and blooming wildflowers for nature lovers.

Lake of the Ozarks, Missouri

Just under three hours away, Lake of the Ozarks delivers the quintessential Midwestern lake resort experience. It’s the go-to spot for boating, watersports, and lakeside relaxation, appealing to families, groups, and anyone looking to soak up summer fun or scenic hiking. Its large, serpentine shape ensures something for everyone, from lively party spots to quiet coves.

Best Hotels to Stay at Lake of the Ozarks

• The Lodge of Four Seasons – Classic full-service resort with golf, family-friendly amenities, a marina, and one of the Midwest's premier spas.
• Margaritaville Lake Resort – Family-friendly with indoor waterparks, pools, and mini-golf; ideal for kids and casual lake vacations.
• Camden on the Lake Resort – Modern entertainment-focused resort with lively nightlife and a swim-up bar, located near live music venues.

Best Restaurants to Try at Lake of the Ozarks

• Baxter's Lakeside Grille – Upscale steak and seafood with panoramic lake views, perfect for a special night out.
• JB's Boathouse Grill – Casual, waterfront dining at the 3.5-mile marker with excellent Grouper Reuben and outdoor seating.
• The Duck Restaurant & Bar – Historic fine dining offering classic steak and duck confit in a cozy atmosphere, ideal for romantic dinners.

Best Things to Do at Lake of the Ozarks

• Boat Rentals: Pontoon or speedboat rentals are the essential way to explore the lake's many arms, find quiet swimming spots, or enjoy watersports.
• Ha Ha Tonka State Park: Hike to geological wonders including sinkholes, caves, a natural bridge, and castle ruins overlooking the lake. Trails range from easy to moderate.
• Bridal Cave: Guided tours through spectacular underground formations provide a cool respite and fascinating adventure for all ages.

2-day Itinerary at Lake of the Ozarks

Day 1: Check in and unwind with swimming or relaxing poolside. Dinner can be casual at a fun lakeside bar and grill, such as Shady Gators or Backwater Jacks.

Day 2: Rent a boat to explore the lake's many beautiful coves and enjoy watersports. Meanwhile, visit Ha Ha Tonka State Park or take a cave tour. For dinner, savor lake views at Baxter's Lakeside Grille.

Insider Local Tips

• The lake is quieter and less expensive in the shoulder seasons of May and September, with pleasant weather and fewer crowds.
• Boating main channel traffic on holiday weekends can be rough and hectic; novice boaters should avoid peak times.
• Book waterfront homes and condos early, preferably by January, to secure the best spots for summer stays.
• For a less-crowded dining experience, explore quieter arms of the lake like the Gravois Arm's 17-mile marker instead of main channel restaurants.

Best Time to Visit Lake of the Ozarks

Summer (Memorial Day through Labor Day) is prime boating and water activity season, when all attractions and resorts are fully open.

Kansas City, Missouri

Kansas City, about 3.75 hours away, offers a vibrant urban escape rich in culture, world-class barbecue, and jazz history that contrasts nicely with St Louis. This mid-range city break is great for foodies, arts enthusiasts, and those seeking a lively nightlife scene. The distinct character and renowned attractions make it a rewarding weekend getaway from St Louis.

Best Hotels to Stay in Kansas City

• The Fontaine – Luxury boutique hotel in the upscale Country Club Plaza with a rooftop pool and breathtaking city views, perfect for romantic stays.
• 21c Museum Hotel Kansas City – Artistic boutique hotel combining lodging with 24/7 contemporary art exhibits for a unique, memorable experience.
• Crossroads Hotel – Trendy, central hotel in the Crossroads Arts District with a popular rooftop bar overlooking downtown, great for nightlife lovers.

Best Restaurants to Try in Kansas City

• Joe's Kansas City Gas Station – Iconic BBQ served in a functioning gas station; a must-visit for casual, authentic barbecue. The Z-Man sandwich is legendary.
• Q39 – Upscale, chef-driven BBQ with reservations recommended. Try the Burnt Ends and Brisket for a splurge-worthy meal paired with craft cocktails.
• Corvino Supper Club & Tasting Room – Fine dining option with live jazz and an inventive menu; the tasting menu or Seaweed Donuts provide a refined culinary experience.

Best Things to Do in Kansas City

• The Nelson-Atkins Museum of Art: A renowned, free art museum with encyclopedic collections and famous giant shuttlecock lawn sculptures.
• National WWI Museum and Memorial: Immersive exhibits and the best city views from the Liberty Memorial Tower, perfect for history buffs.
• Country Club Plaza: A beautiful outdoor shopping area modeled after Seville, Spain, offering fountains, sculptures, and romantic strolls.

2-day Itinerary in Kansas City

Day 1: Arrive, check in, and lunch at the Country Club Plaza before shopping. In the evening, explore the Crossroads Arts District with gallery hopping (especially on First Friday), and dine at Q39.

Day 2: Beat the lunch line by arriving early at Joe's KC. Then, visit the Nelson-Atkins Museum. End the night with live jazz at Green Lady Lounge before heading home.

Insider Local Tips

• If visiting in the first weekend of the month, don’t miss 'First Fridays' where galleries open late with art and entertainment.
• Try multiple BBQ spots to appreciate different styles—from casual gas station fare to upscale dining.
• Popular restaurants like Q39 require reservations at least a week ahead.
• For a unique experience, visit Boulevard Brewing Company's Beer Hall for exclusive brews and a patio.

Best Time to Visit Kansas City

Fall (September–November) is ideal for cooler weather, football, and fewer tourists. Spring (April–June) also offers pleasant temperatures and outdoor-friendly conditions.

Branson, Missouri

About four hours from St Louis, Branson is the quintessential family-friendly destination packed with live entertainment, theme parks, and the scenic charm of the Ozarks. It caters to multiple generations with attractions ranging from thrilling amusement parks to theatrical dinner shows, making it a versatile and lively weekend getaway from St Louis.

Best Hotels to Stay in Branson

• Big Cedar Lodge – Luxury wilderness resort with golf, spa, marina, and rustic-luxe accommodations; perfect for families wanting upscale outdoor experiences.
• Chateau on the Lake Resort Spa – Mid-range resort known as the 'Castle of the Ozarks,' featuring lake views, pools, and marina amenities suitable for families or couples.
• The Keeter Center at College of the Ozarks – Unique student-run lodge offering quiet, family-friendly accommodations and an acclaimed on-site restaurant.

Best Restaurants to Try in Branson

• Dobyns Dining Room at The Keeter Center – Upscale American with farm-to-table ingredients, notable for the Pork Porterhouse and Lobster Bisque. Great for brunch or splurge dinners.
• Gettin' Basted – Award-winning casual barbecue famous for championship ribs and 'Blackout' brisket sandwich, ideal for families.
• Billy Gail's – Quirky breakfast and lunch spot serving gigantic pancakes; a fun, casual experience for all ages.

Best Things to Do in Branson

• Silver Dollar City: An 1880s-themed amusement park with rides, shows, and Ozarks crafts—all shaded and family-friendly.
• Dolly Parton's Stampede: High-energy dinner show featuring horses, riders, special effects, and a four-course meal for a fun, theatrical night.
• Titanic Museum Attraction: Interactive, historic museum housed in a half-scale replica of the ship; engaging for families and history lovers.

2-day Itinerary in Branson

Day 1: Arrive and visit the Titanic Museum. Evening dinner and show at Dolly Parton's Stampede provide unique entertainment.

Day 2: Dedicate the day to Silver Dollar City. If possible, stay for evening performances. Enjoy late dinner off the main strip before resting at the hotel.

Insider Local Tips

• Use marked alternate scenic routes to avoid congestion on busy Highway 76.
• Avoid timeshare presentations unless you have extra time to spare, as they can last multiple hours.
• Purchase show tickets and Silver Dollar City passes online ahead of time for savings and shorter lines.
• For a quieter experience, visit Dewey Short Visitor Center at Table Rock Dam for scenic views and educational exhibits.

Best Time to Visit Branson

Summer (June–August) for full attraction operations, or November–December for Silver Dollar City's popular 'An Old Time Christmas' festivities.

Louisville, Kentucky

Four hours from St Louis, Louisville offers a sophisticated mix of bourbon culture, historic architecture, and a vibrant food scene. It's a solid choice for a mid-range getaway with a blend of southern charm and rich history, including unique sporting attractions and world-class distilleries.

Best Hotels to Stay in Louisville

• The Brown Hotel – Historic luxury with opulent design and home of the iconic Hot Brown sandwich, ideal for romantic, high-end weekends.
• 21c Museum Hotel Louisville – Boutique art hotel blending contemporary exhibits and trendy accommodations, great for art lovers.
• Hotel Distil, Autograph Collection – Modern bourbon-themed hotel on historic Whiskey Row, blending nightlife and proximity to distilleries.

Best Restaurants to Try in Louisville

• Jack Fry's – Upscale Southern cuisine with a classic ambiance; try the Shrimp and Grits or Pork Chop paired with live jazz.
• Proof on Main – New American fare within 21c Museum Hotel boasting inventive dishes and one of the city's best bourbon bars.
• Royals Hot Chicken – Casual, affordable spot serving renowned hot chicken with creative sides and bourbon milkshakes.

Best Things to Do in Louisville

• Urban Bourbon Trail: Explore downtown bars known for their bourbon collections, each offering a distinctive experience and the chance to stamp a passport.
• Louisville Slugger Museum & Factory: See how iconic baseball bats are made, hold legendary bats, and don't miss the giant bat outside.
• Churchill Downs & Kentucky Derby Museum: Explore the storied home of the Derby, including engaging exhibits and a guided tour of the racetrack.

2-day Itinerary in Louisville

Day 1: Check-in and lunch in the NuLu district at Royals Hot Chicken. Explore boutiques and visit the Slugger Museum. Dine at Jack Fry's for a classic, historic experience.

Day 2: Morning at the Kentucky Derby Museum. Afternoon distillery tour (plan for weekday). Evening stroll Whiskey Row and dinner at Proof on Main.

Insider Local Tips

• Many distilleries close Sundays and Mondays; schedule tours midweek for best options.
• Reservation is essential for popular distilleries and upscale restaurants; book weeks ahead.
• During Derby season in early May, book accommodations and dining almost a year in advance due to high demand.
• For a more local vibe, explore the Highlands along Bardstown Road for eclectic shops and bars.

Best Time to Visit Louisville

Spring (April–May) to experience Derby season excitement or fall (September–October) for comfortable weather and bourbon festivals.

Indianapolis, Indiana

Four hours northeast of St Louis, Indianapolis delivers a surprisingly livable and walkable city experience. It's great for families with the world's largest children's museum and zoo, as well as sports fans drawn to racing heritage. The city's cultural scene and burgeoning dining options make it a worthy mid-range weekend getaway from St Louis.

Best Hotels to Stay in Indianapolis

• Bottleworks Hotel – Chic, art deco boutique hotel in a former Coca-Cola plant, anchoring a lively new entertainment district.
• Ironworks Hotel Indy – Industrial-chic with proximity to acclaimed restaurants, great for food-centric travelers seeking a boutique vibe.
• JW Marriott Indianapolis – Modern, centrally located hotel connected to major venues and offering excellent service and views.

Best Restaurants to Try in Indianapolis

• St. Elmo Steak House – Iconic classic steakhouse famous for its fiery world-famous shrimp cocktail; a rite of passage for visitors.
• Milktooth – Innovative brunch spot in a former garage, known for Dutch Baby Pancakes and creative dishes; expect a wait.
• Bluebeard – Romantic, farm-to-table New American dining in a historic factory setting, paired with exceptional bakery breads.

Best Things to Do in Indianapolis

• The Children's Museum of Indianapolis: The largest of its kind globally, packed with immersive exhibits perfect for families.
• Indianapolis Motor Speedway Museum: Dive into the Indy 500 legacy and take a 'Kiss the Bricks' lap on the historic track.
• White River State Park: Expansive urban park with the zoo, museums, and recreational opportunities along the scenic Central Canal Walk.

2-day Itinerary in Indianapolis

Day 1: Check in, stroll or bike the Central Canal Walk in White River State Park. Dine in the Mass Ave arts district and end the night at The Rathskeller beer hall.

Day 2: Early brunch at Milktooth. Spend the day at the Indianapolis Motor Speedway Museum. For dinner, savor the flaming shrimp cocktail at St. Elmo Steak House.

Insider Local Tips

• Expect busy conventions in August and May during the Indy 500; hotel prices rise sharply.
• Parking downtown multiple times is a hassle; park once and explore on foot or via scooter.
• Reservations for St. Elmo Steak House should be made several weeks ahead, especially on weekends.
• Visit the Fountain Square neighborhood for a funkier, artsier scene with unique entertainment.

Best Time to Visit Indianapolis

May during Indy 500 week delivers unmatched excitement, but book well in advance. Fall (September–October) offers pleasant weather and lighter crowds for sightseeing and outdoor activities.

Nashville, Tennessee

A longer road trip at almost five hours, Nashville is worth the extra drive for an energetic 3-day weekend filled with live music, vibrant dining, and cultural depth. Known as Music City, it offers world-class country music venues, booming food culture, and a rich artistic legacy. It's a high-end getaway for those seeking electrifying entertainment and Southern hospitality.

Best Hotels to Stay in Nashville

• The Hermitage Hotel – Historic luxury and Nashville's most iconic hotel. Stunning Beaux-Arts interiors and famous art deco public spaces make it a splurge-worthy choice.
• Thompson Nashville – Modern boutique hotel with a rooftop bar offering spectacular skyline views in the trendy Gulch neighborhood.
• Graduate Nashville – Funky, playful Dolly Parton-themed boutique hotel with a highly Instagrammable rooftop bar and colorful design.

Best Restaurants to Try in Nashville

• Prince's Hot Chicken Shack – The original hot chicken spot, casual and no-frills with legendary spicy fried chicken.
• Husk – Upscale Southern farm-to-table in a historic mansion, with a daily changing menu; try the Shrimp and Grits if available.
• The Bluebird Cafe – Intimate venue famed for singer-songwriter performances; the menu is simple because the music is the star.

Best Things to Do in Nashville

• Grand Ole Opry: Historic country music stage with live radio shows featuring legends and rising stars.
• Country Music Hall of Fame and Museum: Comprehensive exhibits and artifacts tracing country music's evolution.
• Broadway Historic District: Bustling nightlife hub with honky tonk bars offering live music without a cover charge.

3-day Itinerary in Nashville

Day 1: Check in and experience Broadway's honky tonks like Tootsie's. End with famous Nashville Hot Chicken late-night dinner.

Day 2: Visit the Country Music Hall of Fame. Lunch and shop in the Gulch. Evening show at the Grand Ole Opry or Ryman Auditorium.

Day 3: Brunch in the 12South neighborhood, take iconic mural photos, then a bit of souvenir shopping before heading home.

Insider Local Tips

• Broadway is most crowded Friday and Saturday nights; visit on weeknights or weekend days for better music and less noise.
• Explore neighborhoods like The Gulch, 12South, and East Nashville for a local vibe and diverse food scene, beyond Broadway.
• Bluebird Cafe tickets sell out quickly; book online about a week in advance.
• Reserve seats at Grand Ole Opry or Ryman Auditorium at least a month ahead for best options.
• For authentic bluegrass, skip honky tonks and visit The Station Inn in the Gulch.

Best Time to Visit Nashville

Spring (April–May) and Fall (September–October) bring agreeable weather perfect for walking and outdoor activities. Summer can be very hot and humid.

Frequently Asked Questions about Weekend Getaways from St Louis MO

What's the best weekend getaway from St. Louis that's less than a 2-hour drive? Hermann, Missouri, is the top choice, located about 90 minutes away. It offers a charming German-influenced wine country town ideal for romantic or relaxing trips. Shawnee National Forest in Illinois also qualifies as an outdoors-focused nature escape under two hours from St Louis.

Which destinations are best for a romantic weekend versus a family trip? For romance, Hermann's wineries and cozy B&Bs shine, as do the upscale hotels and fine dining in Louisville or Kansas City. Families will find Branson the ultimate pick due to its theme parks and shows, with Indianapolis as a close second thanks to its children's museum and zoo.

How much should I budget for a typical 2-day weekend trip from St. Louis? A budget-friendly nature trip to Shawnee National Forest can cost between $250 and $400. Mid-range city trips like Kansas City or Indianapolis usually range from $500 to $800, covering lodging, food, and activities. High-end or splurge weekends in Nashville or luxury resorts can exceed $1,000.

When is the best time of year to take a weekend trip in the region? Fall (September–October) is the prime season offering pleasant weather, seasonal festivals, and beautiful foliage. Spring (April–May) also provides mild temperatures and blooming landscapes ideal for exploration.

For a city break like Kansas City or Louisville, can I get by without a car? If your lodging is centrally located downtown, core areas such as the Power & Light District in Kansas City or Whiskey Row in Louisville are very walkable. However, to visit attractions outside downtown—like the Nelson-Atkins Museum or Churchill Downs—you'll need a car or rideshare.

Are there any good getaways focused primarily on hiking and nature? Indeed. Shawnee National Forest is the premier hiking destination near St Louis, with iconic sites like the Garden of the Gods. Ha Ha Tonka State Park at the Lake of the Ozarks also offers scenic trails with castle ruins. For a more rugged nature experience, Johnson's Shut-Ins and Elephant Rocks State Parks (about 1.5 hours from St Louis) provide excellent options.

How far in advance do I need to book hotels and activities? During peak seasons or major events—such as Oktoberfest in Hermann or Derby Week in Louisville—book lodging 6 to 12 months in advance. For regular weekends, booking 1 to 2 months ahead is typically adequate. For popular restaurants or tours, reservations 2 to 3 weeks before the trip are advisable.

One of the advantages of living in St Louis is how quickly the scenery, pace, and atmosphere can change with just a few hours on the road. From wine country towns and forested hiking trails to energetic cities and lakeside resorts, these weekend getaways from St Louis make it easy to step away without overplanning or long travel days.

Whether you’re looking for a quiet reset, a food-focused city break, or a fun-filled family escape, each destination offers enough to feel like a true getaway while still fitting comfortably into a short trip. With the right timing and a bit of advance planning, even a simple weekend can feel refreshingly substantial, and close to home.